GPR17, G protein-coupled receptor 17, 2840

N. diseases: 41; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005859
Disease: Bloom Syndrome
Bloom Syndrome 		0.010 AlteredExpression disease BEFREE We found that BLM significantly increased GPR17 expression, the mRNA synthesis and release of inflammatory cytokines including TNF-α, IL-6 and TGF-β1 in murine RAW 264.7 macrophage cells. 30036769 2018
CUI: C0042133
Disease: Uterine Fibroids
Uterine Fibroids 		0.010 GeneticVariation group BEFREE To our knowledge, uterine leiomyoma in association with r(12) has not been reported previously. 8725781 1996
CUI: C4524092
Disease: Chronic rhinosinusitis with nasal polyps
Chronic rhinosinusitis with nasal polyps 		0.010 AlteredExpression disease BEFREE To evaluate the expression of GPR17 and its correlation with CysLT1R in the 2 CRSwNP subsets. 29161055 2018
CUI: C0264716
Disease: Chronic heart failure
Chronic heart failure 		0.010 Biomarker disease BEFREE Thus further research into the therapeutic potential of BB-R12 for patients with chronic heart failure appears warranted. 25876005 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 Biomarker disease BEFREE This ability of R12 highlights its therapeutic potential for treating AD pathology. 30916478 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 Biomarker disease BEFREE These pilot results suggest cardiac-specific gene therapy using BB-R12 may reverse cardiac dysfunction by myosin activation in a large-animal heart failure model with no observed safety concerns. 25876005 2015
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE These pilot results suggest cardiac-specific gene therapy using BB-R12 may reverse cardiac dysfunction by myosin activation in a large-animal heart failure model with no observed safety concerns. 25876005 2015
CUI: C1328504
Disease: Hormone refractory prostate cancer
Hormone refractory prostate cancer 		0.010 Biomarker disease BEFREE These data suggest that compound (R)-12 is a promising lead compound for the development of a new class of therapeutics for the treatment of CRPC. 29758518 2018
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 Biomarker group BEFREE There were only single published cases of most small rings but there were three r(8) cases, two r(1) cases, two r(12) cases, and two r(20) cases, uncomplicated by the presence of other chromosome abnormalities. 7802042 1994
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 GeneticVariation disease BEFREE There was a significant genetic correlation between ovarian and breast cancer (R12 = .484). 2491011 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 GeneticVariation disease BEFREE There was a significant genetic correlation between ovarian and breast cancer (R12 = .484). 2491011 1989
CUI: C0393953
Disease: Anterior Cerebral Circulation Infarction
Anterior Cerebral Circulation Infarction 		0.300 Therapeutic phenotype CTD_human The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 18974869 2008
CUI: C0751952
Disease: Anterior Circulation Brain Infarction
Anterior Circulation Brain Infarction 		0.300 Therapeutic phenotype CTD_human The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 18974869 2008
CUI: C0751953
Disease: Brain Infarction, Posterior Circulation
Brain Infarction, Posterior Circulation 		0.300 Therapeutic phenotype CTD_human The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 18974869 2008
CUI: C0751954
Disease: Venous Infarction, Brain
Venous Infarction, Brain 		0.300 Therapeutic phenotype CTD_human The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. 18974869 2008
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.030 Biomarker disease BEFREE The rats were divided into eight groups randomly: (1) sham-operated group, (2) ischemia group, (3-5) ischemia-reperfusion (middle cerebral artery occlusion and reperfusion (MCAO/R) 12 h, 48 h, and 7 days) and 0.9% saline groups, (6-8) ischemia-reperfusion (MCAO/R 12 h, 48 h, and 7 days) and Ang-1 groups. 21710361 2012
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 Biomarker disease BEFREE The methylation of genes ADCY4, ADCY6 and GPR17, as well as the gonadotropin-releasing hormone signaling pathway, was newly found to be potentially associated with OA.They may be novel OA markers. 27810435 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 GeneticVariation group BEFREE The karyotype of the primary tumor was 46,X,del(X)(p?11p?22), der(12)(12pter→12q?22::12q?15→q?22::16p11→16pter),-16,+r(12). 25176350 2014
CUI: C0027430
Disease: Nasal Polyps
Nasal Polyps 		0.010 AlteredExpression disease BEFREE The increased expression of GPR17 in nasal polyps and the differential expression between eosinophilic and non-eosinophilic CRSwNP subsets suggest that these subsets may have distinct pathogenic mechanisms. 29161055 2018
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.010 Biomarker disease BEFREE The four previously reported cases of r(12) support the theory of a general ring phenotype which is manifested independently of the specific autosome involved and which is characterized by growth failure, moderate mental retardation, and lack of other major phenotypic anomalies. 3354616 1988
CUI: C0878787
Disease: Growth failure
Growth failure 		0.010 Biomarker phenotype BEFREE The four previously reported cases of r(12) support the theory of a general ring phenotype which is manifested independently of the specific autosome involved and which is characterized by growth failure, moderate mental retardation, and lack of other major phenotypic anomalies. 3354616 1988
CUI: C0015652
Disease: Fascioliasis
Fascioliasis 		0.010 Biomarker disease BEFREE The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats. 28362822 2017
CUI: C0007682
Disease: CNS disorder
CNS disorder 		0.010 Biomarker group BEFREE The absence of Gpr17 enhances remyelination is correlate with the activated Erk1/2 (phospho-Erk1/2).Being a membrane receptor, Gpr17 represents an ideal druggable target to be exploited for innovative regenerative approaches to acute and chronic CNS diseases. 29540737 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 Biomarker disease BEFREE The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression. 30640576 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 Biomarker disease BEFREE The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression. 30640576 2019